English
norskBlar i forfatter "Østerud, Bjarne"
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Anti-β2-glycoprotein I autoantibodies influence thrombin generation parameters via various mechanisms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-06)Introduction<p> Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by recurrent thrombotic events, pregnancy loss and thrombocytopenia and the presence of antiphospholipid antibodies (APL). The exact pathomechanism of APS is still unknown, thus we investigated the effect of anti-β2-glycoprotein I (anti-β2GPI) on thrombin generation in different plasma samples.<p> <p>Methods ... -
Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-08)Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than half the amount of LC-n3-PUFA of CLO, CWO supplement resulted in beneficial effects on anti-inflammatory ... -
Antioxidant and Anti-Inflammatory Activities of Barettin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. ... -
Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-03)Study design: This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.<p> <p>Objectives: Tetraplegic patients have an increased risk of venous thrombosis despite prophylaxis, blunted variations in melatonin and altered circadian variation of several hemostatic markers. To examine whether melatonin could modify the regulation of hemostasis, we ... -
Cold-pressed minke whale oil reduces circulating LDL/VLDL-cholesterol, lipid oxidation and atherogenesis in apolipoprotein E-deficient mice fed a Western-type diet for 13 weeks
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-04)Background<br> Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake ... -
Detection of tissue factor in platelets: why is it so troublesome?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood. The latter has been extensively studied in a vast quest for possible sources of blood-borne TF yielding many conflicting findings and confusing conclusions regarding ... -
Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-29)Introduction: Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming ... -
Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)<i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ... -
Prosessering av sjømat – Endring i næringsinnhold, biotilgjengelighet og helseeffekter
(Research report; Forskningsrapport, 2010-11-29)Rapporten oppsummerer hvordan prosessering kan påvirke innholdet av næringsstoffer i sjømat, samt hvordan biotilgjengeligheten til ulike stoffer kan endres som følge av prosessbetingelsene. I tillegg er det kort redegjort for vitenskapelig status på helseeffektene av sjømatkonsum, samt hvilke ernæringsmessige faktorer som gjør sjømat til et særegent næringsmiddel. Økt prosesseringsgrad av sjømat ... -
A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)Background - Most tissue factor (TF) activity assays are based on measurement of factor X (FX) activation by TF in the presence of factor VII (FVII)/FVIIa. This requires long incubation, which may result in TF-independent activity of FX and inaccurate measurement of TF activity.<p> <p>Aim - To develop a sensitive and specific TF activity assay, which does not register a non-specific TF activity, ...
